At Leeder Analytical, our NATA-accredited laboratory provides cutting-edge high-resolution liquid chromatography-mass spectrometry (LC-MS/MS) services specialized in unknown compound identification and structural characterization using state-of-the-art Thermo Fisher Scientific instrumentation.
From emerging contaminants and complex organic mixtures to novel compounds and biological matrices, our advanced Orbitrap technology delivers unprecedented analytical precision and comprehensive compound identification capabilities.
Whether you’re investigating unknown contaminants, conducting pharmaceutical research, or advancing environmental monitoring, we provide detailed molecular insights that enable confident decision-making.
Why Choose Leeder Analytical for High Resolution LC-MS/MS Analysis?
At Leeder Analytical, we transform complex analytical data into actionable intelligence through our advanced Orbitrap LC-MS/MS platform. By combining cutting-edge instrumentation, comprehensive MS/MS libraries, and machine learning-based analysis, we deliver results you can trust and understand.
Here’s what sets our High Resolution LC-MS/MS services apart:
- Advanced Thermo Fisher Scientific Vanquish UHPLC coupled with Exploris Orbitrap MS system
- Sub-ppm mass accuracy for confident molecular formula assignment
- Broad mass range coverage (m/z 50-3000)
- Comprehensive MS/MS library coverage exceeding 1 million compounds
- Machine learning-powered structure elucidation capabilities
Key Benefits of Our High Resolution LC-MS/MS Services:
- Confident Unknown Identification: Determine molecular formulas and structures with high mass accuracy and MS/MS confirmation.
- Comprehensive Library Coverage: Access to multiple complementary MS/MS libraries containing over 1 million compounds, including our curated in-house library.
- Advanced Structure Elucidation: Utilize machine learning and library-free approaches for novel compound identification.
- Detailed Reporting: Receive comprehensive reports including accurate mass, retention time, ion form, chemical formula, and when available, CAS numbers and compound names.
Our High Resolution LC-MS/MS Capabilities:
- Library-Based Analysis: Our extensive MS/MS library resources include:
- In-house authentic standard library (>600 compounds)
- mzCloud database (>32,000 compounds)
- XCMS-METLIN MS/MS library (>935,000 compounds)
- Specialized PFAS library (>40,000 compounds)
- NIST Tandem Mass Spectral Library (>51,000 compounds)
- MS Dial lipid database (117 subclasses, >20,000 molecules)
- Advanced Structure Elucidation: For compounds not found in MS/MS libraries, we employ:
- SIRIUS 6 machine learning analysis
- PubChem structure candidate generation (>117M compounds)
- De novo structure determination
- Expert review and validation
Who We Work With:
Our high-resolution LC-MS/MS services support:
- Environmental Monitoring Organizations: Identifying emerging contaminants and unknown pollutants in environmental samples.
- Pharmaceutical Companies: Characterizing unknown impurities and conducting detailed structural analysis of drug compounds.
- Research Institutions: Supporting metabolomics, proteomics, and other advanced analytical research projects.
- Regulatory Bodies: Providing detailed molecular characterization for compliance and investigation purposes.
Technical Specifications:
- Instrument: Thermo Fisher Scientific Vanquish UHPLC with Exploris Orbitrap MS
- Mass Accuracy: Sub-ppm
- Mass Range: m/z 50-3000
- Analysis Modes: Full scan MS and MS/MS
- Data Processing: Automated workflow combining library searching and machine learning analysis
Get in Touch Ready to discuss your oil spill analysis requirements or establish emergency response protocols? Contact Leeder Analytical today.
Phone: +613 9481 4167
Email: enquiries@leeder-analytical.com
